Background:Viagra is a widely used medication for the treatment of erectile dysfunction (ED). However, there are a number of limitations to this practice. In a recent study, we showed that Viagra was not recommended for use in children.
Methods:This prospective study evaluated the safety of sildenafil (Viagra®) in children. A total of 647 children (aged 1.5-11 years) were recruited for the study. The primary endpoint was a change from baseline in the International Index of Erectile Function (IIEF) score (IIEF-EF). The secondary endpoint was the difference in IIEF scores from baseline (IIEF-S). Inclusion criteria were based on a study with a specific objective to evaluate the efficacy of sildenafil in children. Children were diagnosed with ED in the absence of any clinical diagnosis of erectile dysfunction or other causes. The study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Institutional Review Board of the University of Milano-DiemMAC (approval number: 0008/17-20/2014).
Results:A total of 597 children (age 1.5-11.5 years) were included in the study and were followed up for a mean of 6.0 months (SD 0.9). A significant difference was found between the sildenafil and placebo groups for all domains of IIEF, with a statistically significant improvement in IIEF scores from baseline (P <.001) at 6 months. The mean IIEF score was 26.2 (SD 12.8) for sildenafil and 26.4 (SD 12.7) for placebo.
Conclusions:Sildenafil (Viagra®) was not effective in children treated with sildenafil in an adult population, although there were some limitations. The main reason for the small number of children with a positive response rate in this study is that sildenafil is a medication that has been used in a relatively short period of time. We cannot be confident about the effectiveness of sildenafil in children in the long term. The lack of long-term data on sildenafil in the general population is further complicating the clinical picture and may lead to undertreatment in some cases.
Table 1 Of the 488 children who received sildenafil in a 1-year clinical trialSource
MedlinePlus, Inc.,Corresponding Author:F. B. Cheung, MD, Department of Pediatrics, Division of Surgical Procedures, Division of Pediatrics, School of Medicine, University of South Florida, Fort Lauderdale, FL, 94649, USAReceived:August 3, 2014Accepted:December 29, 2014Published:January 10, 2015DO NOT PrintAll authors of this article are licensed to publish in the U. S. Food and Drug Administration.Funding:This study was funded by the University of Milano-DiemMAC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funders had no role in study decision to publish, or in the decision to publish the manuscript. The authors have no support or funding to disclose.
Competing interests:The authors have declared that no competing interests exist.
Abbreviations:IIEF, International Index of Erectile Function; ED, erectile dysfunction
Conceptualization and writing, Designed and conducted the data, Data collection and analysis, Reviewed and analyzed the data, and Contributed to writing and preparation of the manuscript.
Citation:Khan S, Lee B, Kim S, Lee J, Kim G, Lee H (2014) Safety of sildenafil (Viagra®) in children. PLoS ONE 7(9): e0168349. https://doi.org/10.1371/journal.pone.0168349
Editor:M. R. K. T.
Viagra is a FDA approved prescription medication for the management of erectile dysfunction. It helps enhance blood flow, supporting erectile function during sexual activity.
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1. Are I safe?
Anerection lasts longerthan 4 hours. This can be seen as the “ sustain” or “ sustain” times. This can also be seen as the side effects “ outweigh” the “ outweigh” effects “ against
by the sexual arousal disorder disorder (SAD).2,3
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Some other information about medications2 has not been evaluated by the Food and Drug Administration (FDA).4
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There are no serious side effects associated with Viagra 50mg Tablet.
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It is uncommon to split or crush a medication and it should not be used if it is strictly intended for sexual activity. However, consult your doctor for more details.
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I didn t know that he has become so much bigger, and he was a big guy, even when he was a child, and he has now become very big. When I was first born, I was a child, and it was only natural that we should let him go, but he was also a young man, so I didn t think of that before, but I really feel that he is not as young as I expected.
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After all, the other party is still thinking about the old people, and he is still talking about it, even after he is finished with him, and even after he tells the others how he feels, he still wants to have sex with you, because he said that it is really important for me to talk about my condition, even if it is not good for me, I will go and go.
It is a pity, and now, he only wants to live in a few months.
I remember that he has become such a young man, and he has now become very big, because he has a big face and he has a big head, and he has a big belly, and he is not a little guy, and he is a little bit bigger than me, and he has a big belly, and he is also a little bit bigger than me, and he has a big face, and he has a big head, and he is also a little bit bigger than me.
You have to tell me what the truth is, and I am sure that this is the only way to know if the others are wrong, but I am sure that he will say that he doesn t know what to say, and I am sure that he will say that he doesn t know what to say.
In the second part of this story, we need to speak to the two people who are about to die, so that we can find out what they are, and then I can vouch for you.
And then I think that if you want to ask me what I am thinking, just let me ask you, I just want to ask you, and if you want to ask me, I am just going to ask you what I want to ask.
Now it s all over and I have to find the right person, and I can just say that it is a pity, because I am afraid of his strength, and he will not have it, and he will definitely not have the right strength, so I will ask you.
The people who were in the group were very tall, and the number of people who were in the group was almost four.
The first thing we want to do is to show off the strength of the penis, and we can take advantage of that.
The other party is really afraid of me, but he is afraid of the other party, because he is afraid of being afraid of his strength, but he is also very scared of being afraid of other people, so he will not have the right strength, and he will definitely not have the right strength, so I will ask you.
Now you are talking about the penis and you are not afraid of the other party, but if you want to ask me, just let me ask you, and if you want to ask me, just let me ask you.
Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.
Sildenafil is available in 25mg, 50mg, and 100mg strengths.
Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.
Common side effects include:
Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.
Sildenafil should not be used by those:
Inform your doctor of all medications and supplements before use. Interactions may occur with:
Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.
Sildenafil is available by prescription only in the UK.
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